It takes two to tango: Concerted protein translation and degradation necessary for synaptic scaling | Zendy

Ana Luı́sa Carvalho | Zendy; Dominique Fernandes | Zendy

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It takes two to tango: Concerted protein translation and degradation necessary for synaptic scaling

Author(s) -

Ana Luı́sa Carvalho,

Dominique Fernandes

Publication year - 2021

Publication title -

plos biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 4.127

H-Index - 271

eISSN - 1545-7885

pISSN - 1544-9173

DOI - 10.1371/journal.pbio.3001448

Subject(s) - biology , gene silencing , translation (biology) , microrna , neuroscience , microbiology and biotechnology , synaptic scaling , synaptic plasticity , messenger rna , genetics , receptor , metaplasticity , gene

Synaptic scaling allows neurons to adjust synaptic strength in response to chronic alterations in neuronal activity. A new study in PLOS Biology identifies a pathway that synergizes protein synthesis and degradation with remodeling of the microRNA (miRNA)-induced silencing complex (miRISC) to mediate synaptic scaling.

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