Open AccessIt takes two to tango: Concerted protein translation and degradation necessary for synaptic scaling
Author(s) -
Ana Luı́sa Carvalho,
Dominique Fernandes
Publication year - 2021
Publication title -
plos biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.127
H-Index - 271
eISSN - 1545-7885
pISSN - 1544-9173
DOI - 10.1371/journal.pbio.3001448
Subject(s) - biology , gene silencing , translation (biology) , microrna , neuroscience , microbiology and biotechnology , synaptic scaling , synaptic plasticity , messenger rna , genetics , receptor , metaplasticity , gene
Synaptic scaling allows neurons to adjust synaptic strength in response to chronic alterations in neuronal activity. A new study in PLOS Biology identifies a pathway that synergizes protein synthesis and degradation with remodeling of the microRNA (miRNA)-induced silencing complex (miRISC) to mediate synaptic scaling.