RNA modification of an RNA modifier prevents self-RNA sensing | Zendy

Daltry L. Snider | Zendy; Stacy M. Horner | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

RNA modification of an RNA modifier prevents self-RNA sensing

Author(s) -

Daltry L. Snider,

Stacy M. Horner

Publication year - 2021

Publication title -

plos biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 4.127

H-Index - 271

eISSN - 1545-7885

pISSN - 1544-9173

DOI - 10.1371/journal.pbio.3001342

Subject(s) - biology , rna , rna silencing , mda5 , messenger rna , rna editing , interferon , translation (biology) , adenosine deaminase , ribozyme , microbiology and biotechnology , virology , enzyme , biochemistry , rna interference , gene

A new study in PLOS Biology finds that interferon (IFN)-induced adenosine deaminase acting on RNA 1 ( ADAR1 ) mRNA is N6-methyladenosine (m 6 A) modified to promote its translation, enabling ADAR1 to modify self-double-stranded RNAs (dsRNAs) generated during the IFN response and preventing activation of the melanoma differentiation–associated protein 5 (MDA5)-mediated host antiviral response.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research