Open AccessRNA modification of an RNA modifier prevents self-RNA sensing
Author(s) -
Daltry L. Snider,
Stacy M. Horner
Publication year - 2021
Publication title -
plos biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.127
H-Index - 271
eISSN - 1545-7885
pISSN - 1544-9173
DOI - 10.1371/journal.pbio.3001342
Subject(s) - biology , rna , rna silencing , mda5 , messenger rna , rna editing , interferon , translation (biology) , adenosine deaminase , ribozyme , microbiology and biotechnology , virology , enzyme , biochemistry , rna interference , gene
A new study in PLOS Biology finds that interferon (IFN)-induced adenosine deaminase acting on RNA 1 ( ADAR1 ) mRNA is N6-methyladenosine (m 6 A) modified to promote its translation, enabling ADAR1 to modify self-double-stranded RNAs (dsRNAs) generated during the IFN response and preventing activation of the melanoma differentiation–associated protein 5 (MDA5)-mediated host antiviral response.