How natural killer cells avoid self-destruction when killing their targets | Zendy

Hannah Wurzer | Zendy; Liza Filali | Zendy; Clément Thomas | Zendy

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How natural killer cells avoid self-destruction when killing their targets

Author(s) -

Hannah Wurzer,

Liza Filali,

Clément Thomas

Publication year - 2021

Publication title -

plos biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 4.127

H-Index - 271

eISSN - 1545-7885

pISSN - 1544-9173

DOI - 10.1371/journal.pbio.3001339

Subject(s) - biology , cytotoxic t cell , self tolerance , immunology , microbiology and biotechnology , natural (archaeology) , natural killer cell , lymphokine activated killer cell , natural killer t cell , immune system , interleukin 21 , genetics , autoimmunity , cd8 , in vitro , paleontology

How cytotoxic lymphocytes are protected against their own weapons during close combat with diseased target cells is an important and long-standing question in immunology. A study in this issue provides new insights into the mechanisms by which natural killer (NK) cells avoid self-destruction.

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