Open AccessPiVR: An affordable and versatile closed-loop platform to study unrestrained sensorimotor behavior
Author(s) -
David Tadres,
Matthieu Louis
Publication year - 2020
Publication title -
plos biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.127
H-Index - 271
eISSN - 1545-7885
pISSN - 1544-9173
DOI - 10.1371/journal.pbio.3000712
Subject(s) - phototaxis , optogenetics , biology , chemotaxis , neuroscience , sensory system , drosophila (subgenus) , chemotaxis assay , zebrafish , biochemistry , botany , receptor , gene
Tools enabling closed-loop experiments are crucial to delineate causal relationships between the activity of genetically labeled neurons and specific behaviors. We developed the Raspberry Pi Virtual Reality (PiVR) system to conduct closed-loop optogenetic stimulation of neural functions in unrestrained animals. PiVR is an experimental platform that operates at high temporal resolution (70 Hz) with low latencies (<30 milliseconds), while being affordable (