Open AccessTwo-Tiered Control of Epithelial Growth and Autophagy by the Insulin Receptor and the Ret-Like Receptor, Stitcher
Author(s) -
Fergal O’Farrell,
Shenqiu Wang,
Nadja Sandra Katheder,
Tor Erik Rusten,
Christos Samakovlis
Publication year - 2013
Publication title -
plos biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.127
H-Index - 271
eISSN - 1545-7885
pISSN - 1544-9173
DOI - 10.1371/journal.pbio.1001612
Subject(s) - biology , receptor tyrosine kinase , microbiology and biotechnology , autophagy , tor signaling , pi3k/akt/mtor pathway , receptor , insulin receptor , signal transduction , cell growth , catabolism , receptor protein tyrosine kinases , insulin , endocrinology , genetics , apoptosis , metabolism , insulin resistance
The Drosophila Ret-like receptor, Stit, upholds signaling from the protein complex TORC1 during wing epithelial development, promoting growth under normal conditions and protecting tissues from an anabolic to catabolic switch in response to starvation.