Open AccessThe ING1a Tumor Suppressor Regulates Endocytosis to Induce Cellular Senescence Via the Rb-E2F Pathway
Author(s) -
Uma Karthika Rajarajacholan,
Subhash Thalappilly,
Karl Riabowol
Publication year - 2013
Publication title -
plos biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.127
H-Index - 271
eISSN - 1545-7885
pISSN - 1544-9173
DOI - 10.1371/journal.pbio.1001502
Subject(s) - biology , microbiology and biotechnology , senescence , endocytosis , cyclin d1 , gene knockdown , cell cycle , cell , cell culture , genetics
An age-associated isoform of ING1, ING1a, induces cell senescence by altering endocytosis, subsequently activating the retinoblastoma tumor suppressor.