Serum levels of a subset of cytokines show high interindividual variability and are not altered in rats transgenic for Huntington´s disease | Zendy

Huu Phuc Nguyen | Zendy; Maria Björkqvist | Zendy; Felix J. Bode | Zendy; Michael Stephan | Zendy; Stephan von Hörsten | Zendy

Open Access

Serum levels of a subset of cytokines show high interindividual variability and are not altered in rats transgenic for Huntington´s disease

Author(s) -

Huu Phuc Nguyen,

Maria Björkqvist,

Felix J. Bode,

Michael Stephan,

Stephan von Hörsten

Publication year - 2010

Publication title -

plos currents

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.282

H-Index - 49

ISSN - 2157-3999

DOI - 10.1371/currents.rrn1190

Subject(s) - genetically modified mouse , disease , transgene , huntington's disease , proinflammatory cytokine , peripheral blood , medicine , tumor necrosis factor alpha , immunology , biology , endocrinology , gene , inflammation , genetics

To evaluate whether cytokines are altered in peripheral blood of rats transgenic for the human Huntington´s disease mutation we investigated serum levels of GRO/KC, IL-1β, IL-13 and TNF-α at a symptomatic stage at 12 months of age. Overall serum levels of these cytokines were not significantly changed between transgenic HD rats and controls. Moreover, we observed a high interindividual variability. Our results indicate that these cytokines will be difficult to pursue as biomarkers in at least this rat model of HD.

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