Open AccessKRAS mutational analysis for colorectal cancerApplication: Pharmacogenomic
Author(s) -
Grace Wang,
Robin Kate Kelley,
GAPPNet
Publication year - 2010
Publication title -
plos currents
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.282
H-Index - 49
ISSN - 2157-3999
DOI - 10.1371/currents.rrn1175
Subject(s) - kras , panitumumab , pharmacogenomics , cetuximab , colorectal cancer , medicine , oncology , bioinformatics , cancer , pharmacology , biology
KRAS mutational analysis is a genetic test used in clinical practice for determining the status of the KRAS gene (wild type or mutant) in tumors from patients with metastatic colorectal cancer (CRC). Persons whose tumors are wild type may respond to therapies cetuximab (Erbitux) or panitumumab (Vectibix).