Genetic content of Influenza H3N2 vaccine seeds | Zendy

Corinne Bergeron | Zendy; Martine Valette | Zendy; Bruno Lina | Zendy; Michèle Ottmann | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Genetic content of Influenza H3N2 vaccine seeds

Author(s) -

Corinne Bergeron,

Martine Valette,

Bruno Lina,

Michèle Ottmann

Publication year - 2010

Publication title -

plos currents

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.282

H-Index - 49

ISSN - 2157-3999

DOI - 10.1371/currents.rrn1165

Subject(s) - reassortment , antigenicity , influenza vaccine , virology , biology , hemagglutinin (influenza) , genetics , gene , vaccination , medicine , antibody , covid-19 , disease , pathology , infectious disease (medical specialty)

Influenza vaccine seeds produced in chicken eggs are selected through HA and NA surface glycoproteins antigenicity, as well as through high replicative ability. Here we characterize the genetic content of recently used thirteen H3N2 influenza vaccine seeds. Interestingly, sequence analysis of the vaccine seeds shows reassortment events leading to PR8:H3N2 segment constellations, ranging from the 6:2 to 2:6 constellations. This study shows that the H3N2 PB1 is the most frequent internal segment incorporated in the tested vaccines seeds.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research