Open AccessIdentifying Candidate Targets of Immune Responses in Zika Virus Based on Homology to Epitopes in Other Flavivirus Species
Author(s) -
Xiaojun Xu,
Kerrie Vaughan,
Daniela Weiskopf,
Alba Grifoni,
Michael S. Diamond,
Alessandro Sette,
Bjoern Peters
Publication year - 2016
Publication title -
plos currents
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.282
H-Index - 49
ISSN - 2157-3999
DOI - 10.1371/currents.outbreaks.9aa2e1fb61b0f632f58a098773008c4b
Subject(s) - zika virus , flavivirus , virology , epitope , computational biology , biology , homology (biology) , virus , bioinformatics , genetics , antibody , gene
The current outbreak of Zika virus has resulted in a massive effort to accelerate the development of ZIKV-specific diagnostics and vaccines. These efforts would benefit greatly from the definition of the specific epitope targets of immune responses in ZIKV, but given the relatively recent emergence of ZIKV as a pandemic threat, few such data are available.