Open AccessUtility of a Dengue-Derived Monoclonal Antibody to Enhance Zika Infection In Vitro
Author(s) -
Anu Susan Charles,
Rebecca C. Christofferson
Publication year - 2016
Publication title -
plos currents
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.282
H-Index - 49
ISSN - 2157-3999
DOI - 10.1371/currents.outbreaks.4ab8bc87c945eb41cd8a49e127082620
Subject(s) - virology , dengue virus , dengue fever , serotype , zika virus , flavivirus , antibody , antibody dependent enhancement , monoclonal antibody , heterologous , biology , virus , immunology , biochemistry , gene
Zika virus (ZIKV) has emerged in dengue (DENV) endemic areas, where these two related flaviviruses continue to co-circulate. DENV is a complex of four serotypes and infections can progress to severe disease. It is thought that this is mediated by antibody dependent enhancement (ADE) whereby antibodies from a primary DENV infection are incapable of neutralizing heterologous DENV infections with another serotype. ADE has been demonstrated among other members of the Flavivirus group.