Open AccessBenefits of Pre-natal Taurine Supplementation in Preventing the Onset of Acute Damage in the Mdx Mouse
Author(s) -
Robert G. Barker,
Deanna Horvath,
Chris van der Poel,
Robyn M. Murphy
Publication year - 2017
Publication title -
plos currents
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.282
H-Index - 49
ISSN - 2157-3999
DOI - 10.1371/currents.md.9a3e357a0154d01050b591601cbd4fdb
Subject(s) - taurine , mdx mouse , medicine , duchenne muscular dystrophy , dystrophin , muscular dystrophy , endocrinology , wasting , physiology , amino acid , biology , biochemistry
Duchenne Muscular Dystrophy (DMD) is a debilitating muscle wasting disorder with no cure. Safer supplements and therapies are needed to improve the severity of symptoms, as severe side effects are associated with the only effective treatment, corticosteroids. The amino acid taurine has shown promise in ameliorating dystrophic symptoms in mdx mice, an animal model of DMD, however little work is in 21-28 (d)ay animals, the period of natural peak damage.