Open AccessCorrection: Reduction of Maternal Mortality with Highly Active Antiretroviral Therapy in a Large Cohort of HIV-Infected Pregnant Women in Malawi and Mozambique
Author(s) -
Giuseppe Liotta,
Sandro Mancinelli,
Karin NielsenSaines,
E. Gennaro,
P Scarcella,
N Magid,
Paola Germano,
Haswell Jere,
Giovanni Guidotti,
E Buonomo,
Fausto Ciccacci,
Leonardo Palombi,
Maria Cristina Marazzi
Publication year - 2013
Publication title -
plos one
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.99
H-Index - 332
ISSN - 1932-6203
DOI - 10.1371/annotation/9ab4708e-650e-411a-b72f-bb85e0845469
Subject(s) - antiretroviral therapy , medicine , human immunodeficiency virus (hiv) , cohort , cohort study , pregnancy , obstetrics , viral load , virology , biology , genetics
[This corrects the article on p. e71653 in vol. 8.]. Background. \udHIV infection is a major contributor to maternal mortality in resource-limited settings. The Drug Resource Enhancement Against AIDS and Malnutrition Programme has been promoting HAART use during pregnancy and postpartum for Prevention-of-mother-to-child-HIV transmission (PMTCT) irrespective of maternal CD4 cell counts since 2002.\ud\udMethods.\ud\udRecords for all HIV+ pregnancies followed in Mozambique and Malawi from 6/2002 to 6/2010 were reviewed. The cohort was comprised by pregnancies where women were referred for PMTCT and started HAART during prenatal care (n = 8172, group 1) and pregnancies where women were referred on established HAART (n = 1978, group 2).\ud\udResults.\ud\ud10,150 pregnancies were followed. Median (IQR) baseline values were age 26 years (IQR:23–30), CD4 count 392 cells/mm3 (IQR:258–563), Viral Load log10 3.9 (IQR:3.2–4.4), BMI 23.4 (IQR:21.5–25.7), Hemoglobin 10.0 (IQR: 9.0–11.0). 101 maternal deaths (0.99%) occurred during pregnancy to 6 weeks postpartum: 87 (1.1%) in group 1 and 14 (0.7%) in group 2. Mortality was 1.3% in women with