Open AccessCorrection: Endothelial Membrane Remodeling Is Obligate for Anti-Angiogenic Radiosensitization during Tumor Radiosurgery
Author(s) -
JeanPhilip Truman,
Mónica Garcı́a-Barros,
Matthew Kaag,
Dolores Hambardzumyan,
Branka Stancevic,
Michael D. Chan,
Zvi Fuks,
Richard Kolesnick,
Adriana HaimovitzFriedman
Publication year - 2010
Publication title -
plos one
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.99
H-Index - 332
ISSN - 1932-6203
DOI - 10.1371/annotation/6e222ad5-b175-4a00-9d04-4d120568a897
Subject(s) - obligate , cancer research , radiosurgery , angiogenesis , medicine , chemistry , biology , radiation therapy , ecology
While there is significant interest in combining anti-angiogenesis therapy with conventional anti-cancer treatment, clinical trials have as of yet yielded limited therapeutic gain, mainly because mechanisms of anti-angiogenic therapy remain to a large extent unknown. Currently, anti-angiogenic tumor therapy is conceptualized to either “normalize” dysfunctional tumor vasculature, or to prevent recruitment of circulating endothelial precursors into the tumor. An alternative biology, restricted to delivery of anti-angiogenics immediately prior to single dose radiotherapy (radiosurgery), is provided in the present study.