IsoSense: frequency enhanced sensorless adaptive optics through structured illumination | Zendy

Mantas Žurauskas | Zendy; Ian M. Dobbie | Zendy; Richard M. Parton | Zendy; Michael A. Phillips | Zendy; Antonia Göhler | Zendy; Ilan Davis | Zendy; Martin J. Booth | Zendy

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IsoSense: frequency enhanced sensorless adaptive optics through structured illumination

Author(s) -

Mantas Žurauskas,

Ian M. Dobbie,

Richard M. Parton,

Michael A. Phillips,

Antonia Göhler,

Ilan Davis,

Martin J. Booth

Publication year - 2019

Publication title -

optica

Language(s) - Uncategorized

Resource type - Journals

SCImago Journal Rank - 5.074

H-Index - 107

ISSN - 2334-2536

DOI - 10.1364/optica.6.000370

Subject(s) - adaptive optics , optics , computer science , physics

We present IsoSense, a wavefront sensing method that mitigates sample dependency in image-based sensorless adaptive optics applications in microscopy. Our method employs structured illumination to create additional high spatial frequencies in the image through custom illumination patterns. This improves the reliability of image quality metric calculations and enables sensorless wavefront measurement even in samples with sparse spatial frequency content. We demonstrate the feasibility of IsoSense for aberration correction in a deformable-mirror-based structured illumination super-resolution fluorescence microscope.

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