Open AccessHandheld adaptive optics scanning laser ophthalmoscope
Author(s) -
Theodore B. DuBose,
Derek Nankivil,
Francesco Larocca,
Gar Waterman,
Kristen Hagan,
James Polans,
Brenton Keller,
Du Tran-Viet,
Lejla Vajzovic,
Anthony N. Kuo,
Cynthia A. Toth,
Joseph A. Izatt,
Sina Farsiu
Publication year - 2018
Publication title -
optica
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 5.074
H-Index - 107
ISSN - 2334-2536
DOI - 10.1364/optica.5.001027
Subject(s) - scanning laser ophthalmoscopy , adaptive optics , wavefront sensor , wavefront , footprint , mobile device , ophthalmoscopy , optics , computer science , laser , computer vision , artificial intelligence , retina , physics , biology , paleontology , operating system
Adaptive optics scanning laser ophthalmoscopy (AOSLO) has enabled in vivo visualization and enhanced understanding of retinal structure and function. Current generation AOSLOs have a large footprint and are mainly limited to imaging cooperative adult subjects. To extend the application of AOSLO to new patient populations, we have designed the first portable handheld AOSLO (HAOSLO) system. By incorporating a novel computational wavefront sensorless AO algorithm and custom optics, we have miniaturized our HAOSLO to weigh less than 200 grams. HAOSLO imaged the cones closest to the fovea with a handheld probe in adults and captured the first AO-enhanced image of cones in infants.