Open AccessStimulated Raman scattering spectroscopic optical coherence tomography
Author(s) -
Francisco E. Robles,
Kevin C. Zhou,
Martin C. Fischer,
Warren S. Warren
Publication year - 2017
Publication title -
optica
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 5.074
H-Index - 107
ISSN - 2334-2536
DOI - 10.1364/optica.4.000243
Subject(s) - optical coherence tomography , raman scattering , optics , raman spectroscopy , molecular imaging , coherence (philosophical gambling strategy) , tomography , preclinical imaging , materials science , physics , in vivo , biology , microbiology and biotechnology , quantum mechanics
We integrate spectroscopic optical coherence tomography (SOCT) with stimulated Raman scattering (SRS) to enable simultaneously multiplexed spatial and spectral imaging with sensitivity to many endogenous biochemical species that play an important role in biology and medicine. The combined approach, termed SRS-SOCT, overcomes the limitations of each individual method. Ultimately, SRS-SOCT has the potential to achieve fast, volumetric, and highly sensitive label-free molecular imaging. We demonstrate the approach by imaging excised human adipose tissue and detecting the lipids' Raman signatures in the high-wavenumber region.