Open AccessSimultaneous integrated diffuse optical tomography and functional magnetic resonance imaging of the human brain
Author(s) -
Xiaofeng Zhang,
Vladislav Toronov,
Andrew Webb
Publication year - 2005
Publication title -
optics express
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.394
H-Index - 271
ISSN - 1094-4087
DOI - 10.1364/opex.13.005513
Subject(s) - diffuse optical imaging , optics , attenuation coefficient , magnetic resonance imaging , monte carlo method , optical tomography , physics , detector , tomography , human head , nuclear magnetic resonance , iterative reconstruction , inverse problem , computer science , materials science , absorption (acoustics) , computer vision , mathematics , medicine , mathematical analysis , statistics , radiology
A complete methodology has been developed to integrate simultaneous diffuse optical tomography (DOT) and functional magnetic resonance imaging (MRI) measurements. This includes development of an MRI-compatible optical probe and a method for accurate estimation of the positions of the source and detector optodes in the presence of subject-specific geometric deformations of the optical probe. Subject-specific head models are generated by segmentation of structural MR images. DOT image reconstruction involves solution of the forward problem of light transport in the head using Monte Carlo simulations, and inversion of the linearized problem for small perturbations of the absorption coefficient. Initial results show good co-localization between the DOT images of changes in oxy- and deoxyhemoglobin concentration and functional MRI data.