Open AccessNew multichannel near infrared spectrophotometry system for functional studies of the brain in adults and neonates
Author(s) -
Daniel Haensse,
Péter M. Szabó,
Derek Brown,
JeanClaude Fauchère,
Peter F. Niederer,
H. U. Bucher,
M. Wolf
Publication year - 2005
Publication title -
optics express
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.394
H-Index - 271
ISSN - 1094-4087
DOI - 10.1364/opex.13.004525
Subject(s) - biomedical engineering , finger tapping , near infrared spectroscopy , forearm , infrared spectrophotometry , medicine , materials science , optics , chemistry , anatomy , audiology , physics , chromatography
We have designed a versatile, multi-channel near-infrared spectrophotometry (NIRS) instrument for the purpose of mapping neuronal activation in the neonatal and adult brain in response to motor, tactile, and visual stimulation. The optical linearity, stability, and high signal to noise ratio (>70 dB) of the instrument were demonstrated using an in vitro validation procedure. In vivo measurements on the adult forearm were also performed. Changes in oxygenation, induced by arterial occlusion of the forearm, were recorded and were shown to compare well with measurements acquired using a conventional NIRS instrument. To demonstrate the capabilities of the instrument, functional measurements in adults and neonates were performed. The instrument exhibited the capability to differentiate with a spatial resolution in the order of cm, local activation patterns associated with a finger tapping sequence.