Open AccessInvestigation of bi-phasic tumor oxygen dynamics induced by hyperoxic gas intervention: A numerical study
Author(s) -
Jae Gwan Kim,
Hanli Liu
Publication year - 2005
Publication title -
optics express
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.394
H-Index - 271
ISSN - 1094-4087
DOI - 10.1364/opex.13.004465
Subject(s) - carbogen , hemodynamics , blood flow , hemoglobin , in vivo , oxygen , materials science , inhalation , chemistry , biomedical engineering , anatomy , anesthesia , medicine , biology , microbiology and biotechnology , organic chemistry
This study intends to explore the underlying principle of the biphasic behavior of increases in oxygenated hemoglobin concentration that was observed in vivo from rat breast tumors during carbogen/oxygen inhalation. We have utilized the Finite Element Method (FEM) to simulate the effects of different blood flow rates, in several geometries, on the near infrared measurements. The results show clearly that co-existence of two blood flow velocities can result in a bi-phasic change in optical density, regardless of the orientation of vessels. This study supports our previous hypothesis that the bi-phasic tumor hemodynamic feature during carbogen inhalation results from a well-perfused and a poorly perfused region in the tumor vasculature.