Open AccessOptical coherence tomography contrast enhancement using spectroscopic analysis with spectral autocorrelation
Author(s) -
Desmond C. Adler,
Tony H. Ko,
Paul R. Herz,
James G. Fujimoto
Publication year - 2004
Publication title -
optics express
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.394
H-Index - 271
ISSN - 1094-4087
DOI - 10.1364/opex.12.005487
Subject(s) - optics , optical coherence tomography , contrast (vision) , physics , coherence (philosophical gambling strategy) , autocorrelation , materials science , doppler effect , spectral density , noise (video) , modulation (music) , computer science , mathematics , telecommunications , statistics , quantum mechanics , astronomy , acoustics , artificial intelligence , image (mathematics)
Enhanced tissue contrast in developmental biology specimens is demonstrated in vivo using a new type of spectroscopic optical coherence tomography analysis that is insensitive to spectroscopic noise sources. The technique is based on a statistical analysis of spectral modulation at each image pixel, and provides contrast based on both the intensity of the backscattered light and the distribution of scattering particle sizes. Since the technique does not analyze optical power at absolute wavelengths, it is insensitive to all spectroscopic noise that appears as local Doppler shifts. No exogenous contrast agents or dyes are required, and no additional components are needed to correct for reference arm motion.