Open AccessParticle aggregation monitoring by speckle size measurement; application to blood platelets aggregation
Author(s) -
Y. Piederrière,
Julien Le Meur,
J Cariou,
Jean-François Abgrall,
M. T. Blouch
Publication year - 2004
Publication title -
optics express
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 1.394
H-Index - 271
ISSN - 1094-4087
DOI - 10.1364/opex.12.004596
Subject(s) - speckle pattern , particle size , materials science , optics , platelet aggregation , dynamic light scattering , transmittance , light scattering , particle (ecology) , platelet , scattering , chemistry , nanotechnology , optoelectronics , physics , medicine , oceanography , geology , immunology , nanoparticle
We report on a new method based on speckle size analysis and devoted to particle aggregation measurements. The experimental measurements give the speckle size variation during a salt aggregation process of polystyrene microspheres. The measurements are taken at a fixed monomer concentration, varying the salt concentration. Moreover, we applied this technique to follow blood platelet aggregation, usually monitored with a visible light transmittance photometer (aggregometer). Aggregation process was induced by ADP (adenosine diphosphate) addition, then we measured the speckle size variation versus time at two different ADP concentrations.