Open AccessDetection of neural activity using phase-sensitive optical low-coherence reflectometry
Author(s) -
Taner Akkin,
Digant P. Davé,
Thomas E. Milner,
H. G. Rylander
Publication year - 2004
Publication title -
optics express
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.394
H-Index - 271
ISSN - 1094-4087
DOI - 10.1364/opex.12.002377
Subject(s) - optics , reflectometry , coherence (philosophical gambling strategy) , materials science , optical coherence tomography , interferometry , reflection (computer programming) , phase (matter) , amplitude , light intensity , physics , time domain , quantum mechanics , computer science , computer vision , programming language
We demonstrate non-contact sub-nanometer optical measurement of neural surface displacement associated with action potential propagation. Experimental results are recorded from nerve bundles dissected from crayfish walking leg using a phase-sensitive optical low coherence reflectometer. No exogenous chemicals or reflection coatings are applied. Transient neural surface displacement is less than 1 nm in amplitude, 1 ms in duration and is coincident with action potential arrival to the optical measurement site. Because the technique uses back-reflected light, noninvasive detection of various neuropathies may be possible.