Open AccessMulti-channel velocity multiplexing of single virus detection on an optofluidic chip
Author(s) -
Jennifer A. Black,
Vahid Ganjalizadeh,
Joshua W. Parks,
Holger Schmidt
Publication year - 2018
Publication title -
optics letters/optics index
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.524
H-Index - 272
eISSN - 1071-2763
pISSN - 0146-9592
DOI - 10.1364/ol.43.004425
Subject(s) - multiplexing , polydimethylsiloxane , optics , microfluidics , materials science , optofluidics , lab on a chip , channel (broadcasting) , multi mode optical fiber , optoelectronics , optical fiber , physics , nanotechnology , computer science , telecommunications
Liquid-core waveguide-based optofluidic devices have proven to be valuable tools for analysis of biological samples in fluid. They have enabled single bioparticle sensitivity while maintaining in-plane detection via light-induced fluorescence. The incorporation of multi-spot excitation with multimode interference (MMI) waveguides has enabled spatially and spectrally multiplexed detection of single viruses on an oxide-based optofluidic platform. Here, we introduce a new way of MMI-based multiplexing where multiple analysis channels are placed within a single multi-spot pattern. This stacked channel design enables both velocity and spectral multiplexing of single particles. The principle is demonstrated with differentiated detection of single H3N2 and H1N1 viruses on a polydimethylsiloxane platform.