Multi-channel velocity multiplexing of single virus detection on an optofluidic chip | Zendy

Jennifer A. Black | Zendy; Vahid Ganjalizadeh | Zendy; Joshua W. Parks | Zendy; Holger Schmidt | Zendy

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Multi-channel velocity multiplexing of single virus detection on an optofluidic chip

Author(s) -

Jennifer A. Black,

Vahid Ganjalizadeh,

Joshua W. Parks,

Holger Schmidt

Publication year - 2018

Publication title -

optics letters

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.524

H-Index - 272

eISSN - 1071-2763

pISSN - 0146-9592

DOI - 10.1364/ol.43.004425

Subject(s) - multiplexing , polydimethylsiloxane , optics , microfluidics , materials science , optofluidics , lab on a chip , channel (broadcasting) , multi mode optical fiber , optoelectronics , optical fiber , physics , nanotechnology , computer science , telecommunications

Liquid-core waveguide-based optofluidic devices have proven to be valuable tools for analysis of biological samples in fluid. They have enabled single bioparticle sensitivity while maintaining in-plane detection via light-induced fluorescence. The incorporation of multi-spot excitation with multimode interference (MMI) waveguides has enabled spatially and spectrally multiplexed detection of single viruses on an oxide-based optofluidic platform. Here, we introduce a new way of MMI-based multiplexing where multiple analysis channels are placed within a single multi-spot pattern. This stacked channel design enables both velocity and spectral multiplexing of single particles. The principle is demonstrated with differentiated detection of single H3N2 and H1N1 viruses on a polydimethylsiloxane platform.

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