Open AccessMultimodality endoscopic optical coherence tomography and fluorescence imaging technology for visualization of layered architecture and subsurface microvasculature
Author(s) -
Yan Li,
Joseph Jing,
JinYi Yu,
Buyun Zhang,
Tiancheng Huo,
Qiang Yang,
Zhongping Chen
Publication year - 2018
Publication title -
optics letters/optics index
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.524
H-Index - 272
eISSN - 1071-2763
pISSN - 0146-9592
DOI - 10.1364/ol.43.002074
Subject(s) - optical coherence tomography , preclinical imaging , fluorescence lifetime imaging microscopy , materials science , optics , biomedical engineering , medical imaging , tomography , fluorescence , radiology , medicine , in vivo , physics , microbiology and biotechnology , biology
Endoscopic imaging technologies, such as endoscopic optical coherence tomography (OCT) and near-infrared fluorescence, have been used to investigate vascular and morphological changes as hallmarks of early cancer in the gastrointestinal tract. Here we developed a high-speed multimodality endoscopic OCT and fluorescence imaging system. Using this system, the architectural morphology and vasculature of the rectum wall were obtained simultaneously from a Sprague Dawley rat in vivo. This multimodality imaging strategy in a single imaging system permits the use of a single imaging probe, thereby improving prognosis by early detection and reducing costs.