Open AccessEndoscopic optical coherence tomography enables morphological and subnanometer vibratory imaging of the porcine cochlea through the round window
Author(s) -
Wihan Kim,
Sang-Min Kim,
John S. Oghalai,
Brian E. Applegate
Publication year - 2018
Publication title -
optics letters/optics index
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.524
H-Index - 272
eISSN - 1071-2763
pISSN - 0146-9592
DOI - 10.1364/ol.43.001966
Subject(s) - optical coherence tomography , optics , round window , michelson interferometer , interferometry , cochlea , tomography , materials science , optical tomography , preclinical imaging , middle ear , biomedical engineering , medical imaging , ear canal , astronomical interferometer , physics , anatomy , acoustics , computer science , medicine , in vivo , microbiology and biotechnology , artificial intelligence , biology
A highly phase stable hand-held (HH) endoscopic system has been developed for optical coherence tomography and vibrometry. Designed to transit the ear canal to the middle ear space and peer through the round window (RW), it is capable of imaging the vibratory function of the cochlear soft tissues with subnanometer scale sensitivity. A side-looking, 9 cm long rigid endoscope with a distal diameter of 1.2 mm, was able to fit within the RW niche and provide imaging access. The phase stability was achieved in part by fully integrating a Michelson interferometer into the HH device. Ex vivo imaging of a domestic pig demonstrated the system's ability for functional vibratory imaging of the cochlea via the RW.