Open AccessIn vivo broadband visible light optical coherence tomography probe enables inverse spectroscopic analysis
Author(s) -
James A. Winkelmann,
Aya Eid,
The-Quyen Nguyen,
Tuan Anh Bui,
Ji Yi,
Vadim Backman
Publication year - 2018
Publication title -
optics letters/optics index
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 1.524
H-Index - 272
eISSN - 1071-2763
pISSN - 0146-9592
DOI - 10.1364/ol.43.000619
Subject(s) - optical coherence tomography , optics , materials science , broadband , visible spectrum , image resolution , spectral imaging , characterization (materials science) , tomography , preclinical imaging , physics , in vivo , microbiology and biotechnology , biology
We report the design and characterization of a 6 mm outer diameter pull-back circumferential scanning visible optical coherence tomography probe. The probe's large visible bandwidth (500-695 nm) allowed for inverse spectroscopic analysis and an axial resolution of ∼1.1 μm in tissue. We verify spectral imaging capabilities by measuring microsphere backscattering spectra and demonstrate in vivo spatial nanoscale characterization of tissue.