In vivo broadband visible light optical coherence tomography probe enables inverse spectroscopic analysis | Zendy

James A. Winkelmann | Zendy; Aya Eid | Zendy; TheQuyen Nguyen | Zendy; Thang Bui | Zendy; Ji Yi | Zendy; Vadim Backman | Zendy

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In vivo broadband visible light optical coherence tomography probe enables inverse spectroscopic analysis

Author(s) -

James A. Winkelmann,

Aya Eid,

TheQuyen Nguyen,

Thang Bui,

Ji Yi,

Vadim Backman

Publication year - 2018

Publication title -

optics letters

Language(s) - Uncategorized

Resource type - Journals

SCImago Journal Rank - 1.524

H-Index - 272

eISSN - 1071-2763

pISSN - 0146-9592

DOI - 10.1364/ol.43.000619

Subject(s) - optical coherence tomography , optics , materials science , broadband , visible spectrum , image resolution , spectral imaging , characterization (materials science) , tomography , preclinical imaging , physics , in vivo , microbiology and biotechnology , biology

We report the design and characterization of a 6 mm outer diameter pull-back circumferential scanning visible optical coherence tomography probe. The probe's large visible bandwidth (500-695 nm) allowed for inverse spectroscopic analysis and an axial resolution of ∼1.1 μm in tissue. We verify spectral imaging capabilities by measuring microsphere backscattering spectra and demonstrate in vivo spatial nanoscale characterization of tissue.

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