Open AccessInk-jet printed, blended polymer-based microdisk resonators for controlling non-specific adsorption of biomolecules
Author(s) -
Abdul Nasir,
Rui Yatabe,
Yoshiki Mikami,
Hiroaki Yoshioka,
Nilesh J. Vasa,
Yuji Oki
Publication year - 2021
Publication title -
optics letters/optics index
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.524
H-Index - 272
eISSN - 1071-2763
pISSN - 0146-9592
DOI - 10.1364/ol.412993
Subject(s) - biosensor , biomolecule , materials science , polymer , adsorption , streptavidin , nanotechnology , surface modification , chemical engineering , chemistry , organic chemistry , composite material , biochemistry , biotin , engineering
A blended FC-V-50 and TZ-001 polymer-based microdisk laser was fabricated by the ink-jet printing method and used for biosensing applications. The FC-V-50 polymer has a negative charge due to the presence of carboxyl functional groups, and the TZ-001 polymer has a positive charge due to the tertiary amine group at a pH of seven. In biosensing applications, non-specific adsorption due to opposite charges of biomolecules and microdisk surfaces can adversely affect the performance of the biosensor. By mixing FC-V-50 and TZ-001 polymers in different ratios, the microdisk surface charge was controlled, and the non-specific adsorption of bovine serum albumin and lysozyme was studied. In addition, the label-free biosensing of streptavidin was demonstrated using a blended polymer-based microdisk laser. This work reports, to the best of our knowledge, the first demonstration of a blended polymer microdisk laser for controlling the non-specific adsorption of biomolecules.