Open AccessHigh-speed photoacoustic-guided wavefront shaping for focusing light in scattering media
Author(s) -
Tianrui Zhao,
Sébastien Ourselin,
Tom Vercauteren,
Wenfeng Xia
Publication year - 2021
Publication title -
optics letters/optics index
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.524
H-Index - 272
eISSN - 1071-2763
pISSN - 0146-9592
DOI - 10.1364/ol.412572
Subject(s) - wavefront , optics , speckle pattern , diffuser (optics) , wavefront sensor , scattering , computer science , physics , light source
Wavefront shaping is becoming increasingly attractive as it promises to enable various biomedical applications by breaking through the optical diffusion limit that prevents light focusing at depths larger than∼ 1m min biological tissue. However, despite recent advancements in wavefront shaping technology, such as those exploiting non-invasive photoacoustic-guidance, in vivo demonstrations remain challenging mainly due to rapid tissue speckle decorrelation. In this work, we report a high-speed photoacoustic-guided wavefront shaping method with a relatively simple experimental setup, based on the characterization of a scattering medium with a real-valued intensity transmission matrix. We demonstrated light focusing through an optical diffuser by optimizing 4096 binary amplitude modulation modes of a digital micromirror device within∼ 300m s , leading to a system runtime of 75 µs per input mode, which is 3 orders of magnitude smaller than the smallest runtime reported in literature so far using photoacoustic-guided wavefront shaping. Thus, our method is a solid step forward toward in vivo applications of wavefront shaping.