Open AccessMultiply scattered light tomography and confocal imaging: detecting neovascularization in age-related macular degeneration
Author(s) -
Ann E. Elsner,
Masahiro Miura,
Stephen A. Burns,
Eva Beausencourt,
Christian Kunze,
Linda M. Kelley,
Joseph P. Walker,
Glenn L. Wing,
Paul Raskauskas,
Donald C. Fletcher,
Qienyuan Zhou,
Andreas W. Dreher
Publication year - 2000
Publication title -
optics express
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.394
H-Index - 271
ISSN - 1094-4087
DOI - 10.1364/oe.7.000095
Subject(s) - confocal , optics , macular degeneration , confocal microscopy , materials science , laser , microscope , medical imaging , microscopy , biomedical engineering , medicine , ophthalmology , physics , radiology
A novel technique, Multiply Scattered Light Tomography (MSLT), and confocal Infrared Imaging are used to provide diagnostic information using a comfortable, rapid, and noninvasive method. We investigated these techniques in detecting neovascularization in age-related macular degeneration. The MSLT used a Vertical Cavity Surface Emitting Laser (VCSEL) at 850 nm, while the confocal imaging technique used either the VCSEL or a 790 nm laser diode. Both were implemented into the topographical scanning system (TopSS, Laser Diagnostic Technologies, Inc.) Confocal imaging with both lasers provided different information about neovascularization as a function of focal plane, and different also from MSLT.