Open AccessA method for single particle tracking through a multimode fiber
Author(s) -
Ángel Cifuentes,
Johanna Trägårdh
Publication year - 2022
Publication title -
optics express
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.394
H-Index - 271
ISSN - 1094-4087
DOI - 10.1364/oe.470111
Subject(s) - multi mode optical fiber , tracking (education) , optics , wavefront , particle tracking velocimetry , fiber , physics , particle (ecology) , optical fiber , computer science , materials science , turbulence , particle image velocimetry , psychology , pedagogy , oceanography , composite material , thermodynamics , geology
Multimode optical fiber (MMF) endoscopes have recently gained widespread attention as a novel tool for imaging deep within tissue using light microscopy. We here present a method for particle tracking through the MMF, which overcomes the lack of a fast enough wide-field fluorescence imaging modality for this type of endoscope, namely a discrete implementation of orbital particle tracking. We achieve biologically relevant tracking speeds (up to 1.2 μm/s) despite using a slow SLM for the wavefront shaping. We demonstrate a tracking accuracy of λ/50 for a 0.3 NA fiber and show tracking of a pinhole moving to mimic Brownian motion with diffusion rates of up to 0.3 μm 2 /s.