Open AccessDetection of GDF11 by using a Ti3C2-MXene-based fiber SPR biosensor
Author(s) -
Chunlan Liu,
Rui Wang,
Yabin Shao,
Chen Chen,
Ping Wu,
Yong Wei,
Yachen Gao
Publication year - 2021
Publication title -
optics express
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.394
H-Index - 271
ISSN - 1094-4087
DOI - 10.1364/oe.440585
Subject(s) - surface plasmon resonance , materials science , biosensor , detection limit , fiber , fiber optic sensor , optics , nanotechnology , chromatography , chemistry , physics , nanoparticle , composite material
In the research of resistant aging, the concentration of Growth differentiation factor-11(GDF11) is an indispensable parameter. So the accurate detection of GDF11 is very important in life science and medical cosmetology. Hereby, we proposed and demonstrated a simple method to detect low concentration GDF11 by using fiber surface plasmon resonance (SPR) sensor decorated with two-dimension (2D) material Ti 3 C 2 -MXene and gold nanosphere. The sensitivity of the fiber SPR sensor was increased to be 4804.64nm/RIU. After functionalized with GDF11 antibody, the fiber SPR sensor could specifically recognize GDF11, and the limit of detection (LOD) can reach 0.577pg/L which is 100 times lower than that of single-molecule ELISA method.