Detection of GDF11 by using a Ti3C2-MXene-based fiber SPR biosensor | Zendy

Chunlan Liu | Zendy; Rui Wang | Zendy; Yabin Shao | Zendy; Chen Chen | Zendy; Ping Wu | Zendy; Yong Wei | Zendy; Yachen Gao | Zendy

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Detection of GDF11 by using a Ti₃C₂-MXene-based fiber SPR biosensor

Author(s) -

Chunlan Liu,

Rui Wang,

Yabin Shao,

Chen Chen,

Ping Wu,

Yong Wei,

Yachen Gao

Publication year - 2021

Publication title -

optics express

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.394

H-Index - 271

ISSN - 1094-4087

DOI - 10.1364/oe.440585

Subject(s) - surface plasmon resonance , materials science , detection limit , biosensor , fiber , fiber optic sensor , optics , nanotechnology , chemistry , chromatography , physics , nanoparticle , composite material

In the research of resistant aging, the concentration of Growth differentiation factor-11(GDF11) is an indispensable parameter. So the accurate detection of GDF11 is very important in life science and medical cosmetology. Hereby, we proposed and demonstrated a simple method to detect low concentration GDF11 by using fiber surface plasmon resonance (SPR) sensor decorated with two-dimension (2D) material Ti 3 C 2 -MXene and gold nanosphere. The sensitivity of the fiber SPR sensor was increased to be 4804.64nm/RIU. After functionalized with GDF11 antibody, the fiber SPR sensor could specifically recognize GDF11, and the limit of detection (LOD) can reach 0.577pg/L which is 100 times lower than that of single-molecule ELISA method.

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