Open AccessPhase interrogation surface plasmon resonance hyperspectral imaging sensor for multi-channel high-throughput detection
Author(s) -
Ruibiao Miyan,
Xueliang Wang,
Jie Zhou,
Youjun Zeng,
Junle Qu,
HoPui Ho,
Kaiming Zhou,
Bruce Z. Gao,
Jiajie Chen,
Yufeng Shao
Publication year - 2021
Publication title -
optics express
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 1.394
H-Index - 271
ISSN - 1094-4087
DOI - 10.1364/oe.433052
Subject(s) - optics , surface plasmon resonance , materials science , interference (communication) , phase (matter) , hyperspectral imaging , birefringence , surface plasmon , refractive index , channel (broadcasting) , physics , plasmon , computer science , telecommunications , quantum mechanics , artificial intelligence , nanoparticle , nanotechnology
Phase interrogation surface plasmon resonance (SPR) imaging is, in principle, suitable in multiple samples and high-throughput detection, but the refractive index difference of various samples can be largely varied, while the dynamic range of phase interrogation SPR is narrow. So it is difficult to perform multi-sample detection in phase interrogation mode. In this paper, we successfully designed a multi-channel phase interrogation detection SPR imaging sensing scheme based on a common optical interference path between p- and s-polarized light without using any mechanical moving components. The fixed optical path difference between p- and s-polarized light is introduced by a birefringence crystal to produce sinusoidal spectral interference fringes. We adopted a time-division-multiplexing peak-finding algorithm to track the resonance wavelength so that the detection range can cover every channel. The phase values which carry the high sensitivity signal of the corresponding samples are calculated by the iterative parameter scanning cross-correlation algorithm.