Open Access3D-coherent anti-Stokes Raman scattering Fourier ptychography tomography (CARS-FPT)
Author(s) -
Sandro Heuke,
Hervé Rigneault,
Anne Sentenac
Publication year - 2021
Publication title -
optics express
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 1.394
H-Index - 271
ISSN - 1094-4087
DOI - 10.1364/oe.416290
Subject(s) - optics , raman scattering , ptychography , fourier transform , physics , resolution (logic) , scattering , optical coherence tomography , raman spectroscopy , tomography , microscopy , materials science , diffraction , computer science , artificial intelligence , quantum mechanics
Fourier ptychography tomography (FPT) is a novel computational technique for coherent imaging in which the sample is numerically reconstructed from images acquired under various illumination directions. FPT is able to provide three-dimensional (3D) reconstructions of the complex sample permittivity with an increased resolution compared to standard microscopy. In this work, FPT is applied to coherent anti-Stokes Raman scattering (CARS) imaging. We show on synthetic data that complex third-order susceptibilities can be reconstructed in 3D from a limited number of widefield CARS images. In addition, we observe that the non-linear interaction increases significantly the potential of CARS-FPT compared to linear FPT in terms of resolution. In particular, with a careful choice of the pump and Stokes beam directions, CARS-FPT is able to provide optical sectioning even in transmission configuration.