Open AccessScanning two-photon continuous flow lithography for the fabrication of multi-functional microparticles
Author(s) -
Samira Chizari,
Shreya Udani,
Amin Farzaneh,
Daniel Stoecklein,
Dino Di Carlo,
Jonathan B. Hopkins
Publication year - 2020
Publication title -
optics express
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.394
H-Index - 271
ISSN - 1094-4087
DOI - 10.1364/oe.410090
Subject(s) - galvanometer , optics , fabrication , lithography , materials science , scanning electron microscope , microfluidics , laser scanning , laminar flow , nanotechnology , optoelectronics , laser , physics , medicine , alternative medicine , pathology , thermodynamics
In this work, we demonstrate the high-throughput fabrication of 3D microparticles using a scanning two-photon continuous flow lithography (STP-CFL) technique in which microparticles are shaped by scanning the laser beam at the interface of laminar co-flows. The results demonstrate the ability of STP-CFL to manufacture high-resolution complex geometries of cell carriers that possess distinct regions with different functionalities. A new approach is presented for printing out-of-plane features on the microparticles. The approach eliminates the use of axial scanning stages, which are not favorable since they induce fluctuations in the flowing polymer media and their scanning speed is slower than the speed of galvanometer mirror scanners.