Measuring the spatial distribution of multiply scattered light using a de-scanned image sensor for examining retinal structure contrast | Zendy

Benjamin S. Sajdak | Zendy; Jack Postlewaite | Zendy; Kevin W. Eliceiri | Zendy; Jeremy D. Rogers | Zendy

Open Access

Measuring the spatial distribution of multiply scattered light using a de-scanned image sensor for examining retinal structure contrast

Author(s) -

Benjamin S. Sajdak,

Jack Postlewaite,

Kevin W. Eliceiri,

Jeremy D. Rogers

Publication year - 2020

Publication title -

optics express

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.394

H-Index - 271

ISSN - 1094-4087

DOI - 10.1364/oe.408587

Subject(s) - optics , contrast (vision) , retinal , pixel , spatial frequency , image sensor , image contrast , microscope , light scattering , image resolution , microscopy , computer science , artificial intelligence , physics , scattering , biology , biochemistry

An optical platform is presented for examining intrinsic contrast detection strategies when imaging retinal structure using ex vivo tissue. A custom microscope was developed that scans intact tissue and collects scattered light distribution at every image pixel, allowing digital masks to be applied after image collection. With this novel approach at measuring the spatial distribution of multiply scattered light, known and novel methods of detecting intrinsic cellular contrast can be explored, compared, and optimized for retinal structures of interest.

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