Sub-acoustic resolution optical focusing through scattering using photoacoustic fluctuation guided wavefront shaping | Zendy

Marco A. Inzunza-Ibarra | Zendy; Evolene Premillieu | Zendy; Clemens Grünsteidl | Zendy; Rafael Piestun | Zendy; Todd W. Murray | Zendy

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Sub-acoustic resolution optical focusing through scattering using photoacoustic fluctuation guided wavefront shaping

Author(s) -

Marco A. Inzunza-Ibarra,

Evolene Premillieu,

Clemens Grünsteidl,

Rafael Piestun,

Todd W. Murray

Publication year - 2020

Publication title -

optics express

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.394

H-Index - 271

ISSN - 1094-4087

DOI - 10.1364/oe.385320

Subject(s) - wavefront , optics , diffuser (optics) , scattering , signal (programming language) , physics , light scattering , photoacoustic effect , photoacoustic imaging in biomedicine , materials science , computer science , light source , programming language

Focusing light through turbid media using wavefront shaping generally requires a noninvasive guide star to provide feedback on the focusing process. Here we report a photoacoustic guide star mechanism suitable for wavefront shaping through a scattering wall that is based on the fluctuations in the photoacoustic signals generated in a micro-vessel filled with flowing absorbers. The standard deviation of photoacoustic signals generated from random distributions of particles is dependent on the illumination volume and increases nonlinearly as the illumination volume is decreased. We harness this effect to guide wavefront shaping using the standard deviation of the photoacoustic response as the feedback signal. We further demonstrate sub-acoustic resolution optical focusing through a diffuser with a genetic algorithm optimization routine.

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