Open AccessSensitivity analysis of Raman endoscopy with and without wavefront shaping
Author(s) -
Lyubov V. Amitonova,
Johannes F. de Boer
Publication year - 2020
Publication title -
optics express
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.394
H-Index - 271
ISSN - 1094-4087
DOI - 10.1364/oe.383801
Subject(s) - wavefront , optics , sensitivity (control systems) , miniaturization , raman spectroscopy , materials science , optical fiber , endoscopy , computer science , physics , nanotechnology , electronic engineering , surgery , medicine , engineering
Vibrational spectroscopy is a powerful method for the label-free identification of molecules. Spontaneous Raman spectroscopy integrated with an ultra-thin fiber-based endoscope can provide remote, local, and minimally invasive chemical analysis in many fields from biomedical diagnostics to the materials industry. Miniaturization of the probe in combination with a large field of view (FOV) and high sensitivity would be beneficial for a broad class of applications. Here we quantitatively analyze signal-to-noise ratio (SNR) and the sensitivity improvement due to wavefront shaping. We show that wavefront shaping in an ultra-thin single-fiber probe allows to decrease the total measurements time up to several orders of magnitude even without any prior knowledge of the Raman particle location. Such a fiber probe is well suited for minimally-invasive endoscopy in biological and medical applications.