Open Access3D microphotonic probe for high resolution deep tissue imaging
Author(s) -
Mohammad Amin Tadayon,
Shriddha Chaitanya,
Kelly M. Martyniuk,
Josephine C. McGowan,
Samantha P. Roberts,
Christine A. Denny,
Michal Lipson
Publication year - 2019
Publication title -
optics express
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.394
H-Index - 271
ISSN - 1094-4087
DOI - 10.1364/oe.27.022352
Subject(s) - miniaturization , optics , photolithography , materials science , microscopy , microscope , resolution (logic) , image resolution , optoelectronics , nanotechnology , physics , computer science , artificial intelligence
Ultra-compact miniaturized optical components for microendoscopic tools and miniaturized microscopes are required for minimally invasive imaging. Current microendoscopic technologies used for deep tissue imaging procedures are limited to a large diameter and/or low resolution due to manufacturing restrictions. We demonstrate a platform for miniaturization of an optical imaging system for microendoscopic applications with a resolution of 1 µm. We designed our probe using cascaded micro-lenses and waveguides (lensguide) to achieve a probe as small as 100 µm x 100 µm with a field of view of 60 µm in diameter. We demonstrate wide-field microscopy based on our polymeric probe fabricated using photolithography and a two-photon polymerization process.