Open AccessBeyond Born-Rytov limit for super-resolution optical diffraction tomography
Author(s) -
Joowon Lim,
Abdul Wahab,
GwangSik Park,
KyeoReh Lee,
Yong Keun Park,
Jong Chul Ye
Publication year - 2017
Publication title -
optics express
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 1.394
H-Index - 271
ISSN - 1094-4087
DOI - 10.1364/oe.25.030445
Subject(s) - optics , scattering , imaging phantom , diffraction tomography , diffraction , physics , forward scatter , limit (mathematics) , focus (optics) , observable , image quality , tomography , refractive index , born approximation , resolution (logic) , computer science , mathematics , image (mathematics) , mathematical analysis , artificial intelligence , quantum mechanics
Optical diffraction tomography (ODT) using Born or Rytov approximation suffers from severe distortions in reconstructed refractive index (RI) tomograms when multiple scattering occurs or the scattering signals are strong. These effects are usually seen as a significant impediment to the application of ODT because multiple scattering is directly linked to an unknown object itself rather than a surrounding medium, and a strong scatter invalidates the underlying assumptions of the Born and Rytov approximations. The focus of this article is to demonstrate for the first time that multiple scattering and high material contrast, if handled aptly, can significantly improve the image quality of the ODT thanks to multiple scattering inside a sample. Experimental verification using various phantom and biological cells substantiates that we not only revealed the structures that were not observable using the conventional approaches but also resolved the long-standing problem of missing cones in the ODT.