Open AccessImproved self-referenced biosensing with emphasis on multiple-resonance nanorod sensors
Author(s) -
Ahmed Abumazwed,
Wakana Kubo,
Takuo Tanaka,
Andrew G. Kirk
Publication year - 2017
Publication title -
optics express
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.394
H-Index - 271
ISSN - 1094-4087
DOI - 10.1364/oe.25.024803
Subject(s) - nanorod , refractive index , materials science , nanoimprint lithography , wavelength , resonance (particle physics) , optics , surface plasmon resonance , sensitivity (control systems) , biosensor , finite element method , emphasis (telecommunications) , lithography , optoelectronics , nanotechnology , computer science , fabrication , physics , electronic engineering , telecommunications , thermodynamics , medicine , alternative medicine , pathology , particle physics , nanoparticle , engineering
We present a novel approach to improve self-referenced sensing based on multiple-resonance nanorod structures. The method employs the maximum likelihood estimation (MLE) alongside a linear response model (LM), relating the sensor response (shifts in resonance wavelengths) to the changes due to surface binding and bulk refractive index. We also provide a solution to avoid repetitive simulations, that have been previously needed to determine the adlayer thickness sensitivity when measuring biological samples of different refractive indices. The finite element method (FEM) was used to model the nanorod structure, and the nanoimprint lithography was employed to fabricate them. The standard deviation of the results based on the MLE method is lower than that associated with the LM results. The method can be applied to an extended number of resonances to achieve a higher accuracy and precision.