Open AccessOxygen saturation estimation in brain tissue using diffuse reflectance spectroscopy along stereotactic trajectories
Author(s) -
Peter Rejmstad,
Peter Zsigmond,
Karin Wårdell
Publication year - 2017
Publication title -
optics express
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.394
H-Index - 271
ISSN - 1094-4087
DOI - 10.1364/oe.25.008192
Subject(s) - diffuse reflectance infrared fourier transform , white matter , reflectivity , diffuse reflection , nuclear medicine , deep brain stimulation , diffuse optical imaging , brain tissue , optics , white light , nuclear magnetic resonance , materials science , biomedical engineering , chemistry , medicine , magnetic resonance imaging , physics , pathology , tomography , radiology , biochemistry , photocatalysis , catalysis , disease , parkinson's disease
Diffuse reflectance spectroscopy (DRS) can be used to estimate oxygen saturation (SO 2 ) of hemoglobin and blood fraction (f B ) in brain tissue. The aim of the study was to investigate the SO 2 and f B in different positions along deep brain stimulation (DBS) trajectories and in specific target regions using DRS and a novel algorithm. DRS measurements were done at 166 well-defined anatomical positions in relation to stereotactic DBS-implantation along 20 trajectories toward 4 DBS targets (STN, Vim, GPi and Zi). The measurements were dived into groups (gray, white and light gray matter) related to anatomical position, and DBS targets, before comparison and statistical analysis. The median SO 2 in gray, white and light gray matter were 52%, 24% and 20%, respectively. Median f B in gray matter (3.9%) was different from values in white (1.0%, p < 0.05) and light gray (0.9%, p < 0.001) matter. No significant difference in median SO 2 and f B was found between DBS target regions. The novel algorithm allows for quick and reliable estimation of SO 2 and f B in human brain tissue.