Mesoporous nanospheres functionalized optical microfiber biosensor for low concentration neurotransmitter detection | Zendy

Mingfei Ding | Zendy; Yunyun Huang | Zendy; Tuan Guo | Zendy; LiPeng Sun | Zendy; BaiOu Guan | Zendy

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Mesoporous nanospheres functionalized optical microfiber biosensor for low concentration neurotransmitter detection

Author(s) -

Mingfei Ding,

Yunyun Huang,

Tuan Guo,

LiPeng Sun,

BaiOu Guan

Publication year - 2016

Publication title -

optics express

Language(s) - Uncategorized

Resource type - Journals

SCImago Journal Rank - 1.394

H-Index - 271

ISSN - 1094-4087

DOI - 10.1364/oe.24.027152

Subject(s) - biosensor , microfiber , materials science , mesoporous material , interferometry , detection limit , silicon dioxide , optics , molecule , wavelength , nanotechnology , silicon , optoelectronics , chemistry , chromatography , biochemistry , physics , organic chemistry , metallurgy , composite material , catalysis

A label-free and ultrasensitive microfiber interferometer biosensor has been demonstrated for detection of neurotransmitter molecule (5-HT). The surface morphology of the silicon dioxide nanospheres acting as molecule sieve provides an effective mean of gathering 5-HT molecules by designed mesoporous structure. The slight concentration change of 5-HT molecules is translated into a dramatic wavelength shift of the interferometric fringe pattern. The experimental results show that the biosensor has a linear response in concentration range from 100 fM to 1 µM and a detection limit as low as 84 fM.

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