Open AccessMesoporous nanospheres functionalized optical microfiber biosensor for low concentration neurotransmitter detection
Author(s) -
Meng Ding,
Yunyun Huang,
Tuan Guo,
Li-Peng Sun
Publication year - 2016
Publication title -
optics express
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 1.394
H-Index - 271
ISSN - 1094-4087
DOI - 10.1364/oe.24.027152
Subject(s) - biosensor , microfiber , materials science , mesoporous material , interferometry , detection limit , silicon dioxide , optics , molecule , wavelength , nanotechnology , silicon , optoelectronics , chemistry , chromatography , biochemistry , physics , organic chemistry , metallurgy , composite material , catalysis
A label-free and ultrasensitive microfiber interferometer biosensor has been demonstrated for detection of neurotransmitter molecule (5-HT). The surface morphology of the silicon dioxide nanospheres acting as molecule sieve provides an effective mean of gathering 5-HT molecules by designed mesoporous structure. The slight concentration change of 5-HT molecules is translated into a dramatic wavelength shift of the interferometric fringe pattern. The experimental results show that the biosensor has a linear response in concentration range from 100 fM to 1 µM and a detection limit as low as 84 fM.