Open AccessHybrid cavity-coupled plasmonic biosensors for low concentration, label-free and selective biomolecular detection
Author(s) -
Abraham VázquezGuardado,
A. Ezekiel Smith,
Wade Wilson,
Jeanette Ortega,
J. Manuel Perez,
Debashis Chanda
Publication year - 2016
Publication title -
optics express
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.394
H-Index - 271
ISSN - 1094-4087
DOI - 10.1364/oe.24.025785
Subject(s) - biosensor , materials science , analyte , plasmon , nanotechnology , atomic layer deposition , surface plasmon resonance , surface plasmon , nanoparticle , layer (electronics) , optoelectronics , optics , chemistry , physics
Simple optical techniques that can accurately and selectively identify organic and inorganic material in a reproducible manner are of paramount importance in biological sensing applications. In this work, we demonstrate that a nanoimprinted plasmonic pattern with locked-in dimensions supports sharp deterministic hybrid resonances when coupled with an optical cavity suitable for high sensitive surface detection. The surface sensing property of this hybrid system is quantified by precise atomic layer growth of aluminum oxide using the atomic layer deposition technique. The analyte specific sensing ability is demonstrated in the detection of two dissimilar analytes, inorganic amine-coated iron oxide nanoparticles and organic streptavidin protein. Femto to nanomolar detection limits were achieved with the proposed coupled plasmonic system based on the versatile and robust soft nanoimprinting technique, which promises practical low cost biosensors.