Differentiation of normal and leukemic cells by 2D light scattering label-free static cytometry | Zendy

Linyan Xie | Zendy; Qiao Liu | Zendy; Changshun Shao | Zendy; Xuantao Su | Zendy

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Differentiation of normal and leukemic cells by 2D light scattering label-free static cytometry

Author(s) -

Linyan Xie,

Qiao Liu,

Changshun Shao,

Xuantao Su

Publication year - 2016

Publication title -

optics express

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.394

H-Index - 271

ISSN - 1094-4087

DOI - 10.1364/oe.24.021700

Subject(s) - cytometry , light scattering , scattering , flow cytometry , optics , materials science , physics , medicine , immunology

Two-dimensional (2D) light scattering patterns of single microspheres, normal granulocytes and leukemic cells are obtained by label-free static cytometry. Statistical results of experimental 2D light scattering patterns obtained from standard microspheres with a mean diameter of 4.19 μm agree well with theoretical simulations. High accuracy rates (greater than 92%) for label-free differentiation of normal granulocytes and leukemic cells, both the acute and chronic leukemic cells, are achieved by analyzing the 2D light scattering patterns. Our label-free static cytometry is promising for leukemia screening in clinics.

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