Open AccessContrast-enhanced continuous-terahertz-wave imaging based on superparamagnetic iron oxide nanoparticles for biomedical applications
Author(s) -
Rui Zhang,
Liangliang Zhang,
Tong Wu,
Shasha Zuo,
Ruixue Wang,
Cunlin Zhang,
Jue Zhang,
Jing Fang
Publication year - 2016
Publication title -
optics express
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.394
H-Index - 271
ISSN - 1094-4087
DOI - 10.1364/oe.24.007915
Subject(s) - terahertz radiation , materials science , optics , miniaturization , continuous wave , superparamagnetism , magnetic particle imaging , nanoparticle , contrast (vision) , reflection (computer programming) , magnetic nanoparticles , nuclear magnetic resonance , optoelectronics , magnetic field , nanotechnology , magnetization , laser , physics , computer science , quantum mechanics , programming language
We present a novel contrast-enhanced continuous-terahertz-wave imaging modality based on magnetic induction heating of superparamagnetic iron oxide nanoparticles (SPIOs), which yields a highly sensitive increment in the reflection terahertz (THz) signal in SPIO solution upon exposure to an alternating magnetic field. In the differential and relative refection change focal-plane images before and after alternating magnetic field exposure, a dramatic contrast is demonstrated between water with and without SPIOs. This low-cost, simple, and stable contrast-enhanced continuous-THz-wave imaging system is suitable for miniaturization and real-time imaging application.