Open AccessFemtoliter-scale optical nanofiber sensors
Author(s) -
Lei Zhang,
Zhiyong Li,
Jinxia Mu,
Wei Fang,
Limin Tong
Publication year - 2015
Publication title -
optics express
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 1.394
H-Index - 271
ISSN - 1094-4087
DOI - 10.1364/oe.23.028408
Subject(s) - nanofiber , materials science , refractive index , optics , optical fiber , microfluidics , optoelectronics , nanotechnology , physics
We report a robust and sensitive optical nanofiber sensor with a femtoliter-scale detection volume. The sensor is fabricated by embedding a 800-nm-diameter nanofiber into a microfluidic chip with probing light propagated perpendicular to a 5-μm-wide detection channel. To verify the effectiveness of the sensor, we present measurements of fluorescence intensity and refractive index (RI) with detection limits of 1 × 10(-7) M for fluorescein and 2.8 × 10(-4) RIU, respectively. The femtoliter-scale optical nanofiber sensor shown here may provide a compact and versatile sensing platform for sensitive and fast detection of ultra-low-volume samples, as well as studying the dynamics of single molecule.