Open AccessJitter reduction technique for acoustic radiation force impulse microscopy via photoacoustic detection
Author(s) -
Bong Jin Kang,
Changhan Yoon,
Jin Man Park,
Jae Youn Hwang,
K. Kirk Shung
Publication year - 2015
Publication title -
optics express
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 1.394
H-Index - 271
ISSN - 1094-4087
DOI - 10.1364/oe.23.019166
Subject(s) - jitter , impulse (physics) , acoustic radiation force , optics , transducer , materials science , acoustic microscopy , imaging phantom , acoustics , impulse response , laser , microscopy , ultrasound , physics , computer science , telecommunications , mathematical analysis , mathematics , quantum mechanics
We demonstrate a jitter noise reduction technique for acoustic radiation force impulse microscopy via photoacoustic detection (PA-ARFI), which promises to be capable of measuring cell mechanics. To reduce the jitter noise induced by Q-switched pulsed laser operated at high repetition frequency, photoacoustic signals from the surface of an ultrasound transducer are aligned by cross-correlation and peak-to-peak detection, respectively. Each method is then employed to measure the displacements of a target sample in an agar phantom and a breast cancer cell due to ARFI application, followed by the quantitative comparison between their performances. The suggested methods for PA-ARFI significantly reduce jitter noises, thus allowing us to measure displacements of a target cell due to ARFI application by less than 3 μm.