Open Access17-μm spectroscopic spectral-domain optical coherence tomography for imaging lipid distribution within blood vessel
Author(s) -
Masato Tanaka,
Mitsuharu Hirano,
K. Murashima,
Hiroshi Obi,
Ryo Yamaguchi,
Takemi Hasegawa
Publication year - 2015
Publication title -
optics express
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 1.394
H-Index - 271
ISSN - 1094-4087
DOI - 10.1364/oe.23.006645
Subject(s) - optical coherence tomography , optics , spectral imaging , materials science , spectrometer , preclinical imaging , in vivo , physics , microbiology and biotechnology , biology
We have developed a spectroscopic optical coherence tomography (OCT) for imaging lipid distribution within blood vessel in order to detect coronary artery plaque. A 1.7-μm spectral-domain OCT with A-scan rate of 47 kHz is fabricated using a broadband light source based on super-luminescent diodes and spectrometers based on extended InGaAs line sensors. We demonstrate imaging of lipid distribution in an in vitro artery model with lipid. The sensitivity and specificity in the differentiation between artery and lipid are 87% and 90% in the training, respectively. The validation test also shows detection of lipid with an accuracy over 90%.