Open AccessAn ultra-low detection-limit optofluidic biosensor based on all glass Fabry-Perot cavity
Author(s) -
Haibo Wu,
Hui Huang,
Min Bai,
Pengbo Liu,
Ming Yu Chao,
Jie Hu,
Jian Hao,
Tun Cao
Publication year - 2014
Publication title -
optics express
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.394
H-Index - 271
ISSN - 1094-4087
DOI - 10.1364/oe.22.031977
Subject(s) - materials science , refractive index , optics , fabry–pérot interferometer , surface plasmon resonance , biosensor , detection limit , surface plasmon , resonator , optoelectronics , wavelength , plasmon , nanotechnology , statistics , physics , mathematics , nanoparticle
An all glass optofludic biosensor with high quality-factor Fabry-Perot cavity (FPC) channel was reported. The all glass sandwich structure can completely eliminate the etching roughness of the channel surface, and can extend the operating wavelength to visible and ultraviolet regions compared with that of Si-based sensor. The quality-factor of the FPC channel is 875, and the system noise can be reduced to 1.2 nV by combining optical differential detection with phase lock-in detection. A detection limit of 15ng/mL for glucose solution, which corresponds to a refractive index unit of 2.0 × 10 -9 , was experimentally demonstrated. The all glass FPC sensor features low cost and robust compared with surface-plasmon-resonance sensor and ring-resonator sensor.